Name: 3-Chloro-2-hydroxypropyltrimethylammonium Chloride
Synonyms: CHPTAC, Quaternary Ammonium Compound, (3-Chloro-2-hydroxypropyl)trimethylammonium chloride
Recommended Uses: Wet-strength agent, chemical intermediate for cationic starches and resins, paper and textile industry processing.
Manufacturer: Chemical production organizations specializing in quaternary ammonium compounds
Contact Information: Emergency phone lines available through national poison control centers and chemical support services.
Classification: Skin and eye irritant; hazardous to aquatic life with long-lasting effects as per GHS classification
Signal Word: Warning
Hazard Statements: Causes skin irritation. Causes serious eye irritation. May be harmful if swallowed or inhaled. Toxic to aquatic life.
Pictograms: Exclamation mark, Environment
Precautionary Statements: Avoid breathing mist, vapors, and spray. Wash hands thoroughly after handling. Wear eye and skin protection. Avoid release to the environment. In case of fire: Use appropriate extinguishing measures. In case of skin or eye contact, rinse immediately with plenty of water.
Chemical Name: 3-Chloro-2-hydroxypropyltrimethylammonium chloride
CAS Number: 3327-22-8
Concentration: Usually 60-70% solution in water
Formulation: May be mixed with stabilizers or water, but contains no significant impurities that contribute to hazard classification in typical industrial supply.
Inhalation: Remove from area to fresh air. Get medical attention if symptoms persist.
Skin Contact: Remove contaminated clothing and shoes. Rinse affected area with plenty of water for 15 minutes. Consult a physician for persistent irritation.
Eye Contact: Flush eyes with large amounts of water for at least 15 minutes, lifting eyelids occasionally. Seek prompt medical advice.
Ingestion: Do not induce vomiting. Rinse mouth with water. Never give anything by mouth to an unconscious person. Contact poison control or a physician immediately.
Most Important Symptoms and Effects: Redness and pain on contact, potential gastrointestinal discomfort if swallowed, risk of chemical conjunctivitis for eye exposure.
Suitable Extinguishing Media: Water spray, dry powder, carbon dioxide, alcohol-resistant foam
Unsuitable Extinguishing Media: None known for this compound
Specific Hazards from the Chemical: Thermal decomposition can release toxic and corrosive gases including hydrogen chloride and nitrogen oxides
Protective Equipment: Firefighters need self-contained breathing apparatus and full protective clothing
Special Precautions: Cool exposed containers with water spray. Stay upwind of fire and keep unnecessary personnel away.
Personal Precautions: Evacuate area. Wear suitable personal protection like gloves, goggles, and chemical-resistant clothing to prevent skin and eye contact.
Environmental Precautions: Prevent runoff into waterways, sewers, and soil. Notify authorities in accordance with local regulations.
Method for Containment and Cleanup: Absorb spillage with inert material such as sand or earth. Use nonsparking tools. Dispose of residue and contaminated material in accordance with regulations. Clean up surface with detergent solution to remove residues.
Handling: Use with adequate ventilation. Avoid all contact with skin, eyes, and clothing. Do not eat, drink, or smoke around the material. Handle outside confined spaces. Wash thoroughly after use.
Storage: Store in cool, dry, well-ventilated areas. Keep containers tightly closed and away from incompatible materials such as strong oxidizers and acids. Protect from sunlight and sources of heat. Store in corrosion-resistant containers clearly labeled.
Specific Storage Requirements: Use secondary containment to prevent leaks or spills from spreading.
Engineering Controls: Use local exhaust ventilation or process enclosures. Eye wash stations and emergency showers should be readily accessible.
Respiratory Protection: Wear approved respirator in situations where exposure may occur above occupational limits, or if ventilation is poor.
Hand Protection: Chemical-resistant gloves such as nitrile or neoprene.
Eye Protection: Goggles or full-face shield.
Skin and Body Protection: Chemical-resistant apron and work clothing.
Hygiene: Wash hands thoroughly before breaks, after handing material, and at shift end. Contaminated clothing should not leave the workplace.
Appearance: Clear to pale-yellow liquid
Odor: Mild ammoniacal
Odor Threshold: Not established
pH: 4-6 (typically)
Melting Point/Freezing Point: Below -20°C (as aqueous solution)
Boiling Point: Above 100°C (solution dependent)
Flash Point: Above 100°C, not classified as flammable
Evaporation Rate: Comparable to water
Flammability: Not considered flammable
Vapor Pressure: Low at ambient conditions
Solubility: Completely soluble in water
Partition Coefficient (n-octanol/water): Not determined
Viscosity: Low to moderate, depending on concentration
Decomposition Temperature: Above 200°C
Chemical Stability: Stable under normal storage and handling conditions.
Conditions to Avoid: Excess heat, direct sunlight, incompatible materials, freezing.
Incompatible Materials: Strong oxidizing agents, strong acids.
Hazardous Decomposition Products: Hydrogen chloride, trimethylamine, nitrogen oxides.
Hazardous Reactions: Polymerization does not occur under standard handling.
Likely Routes of Exposure: Inhalation, skin and eye contact, ingestion.
Acute Toxicity: Low to moderate toxicity by oral and dermal routes; inhalation of aerosols may cause irritation of respiratory tract.
Symptoms: Skin redness, burning, eye tearing, stomach or throat discomfort if swallowed.
Long-Term Effects: Frequent or prolonged skin contact may cause dermatitis.
Carcinogenicity: Not listed by IARC, NTP, or OSHA as a carcinogen.
Mutagenicity and Reproductive Effects: Data do not indicate significant concerns at occupational exposure levels.
Sensitization: Unlikely, but repeated exposure might cause allergic reaction in predisposed individuals.
Ecotoxicity: Toxic to aquatic organisms. Even low concentrations may disrupt aquatic environments.
Persistence and Degradability: Expected to be slowly biodegradable.
Bioaccumulative Potential: Low, based on physical-chemical properties.
Mobility in Soil: Expected to exhibit moderate mobility due to water solubility.
Other Adverse Effects: Spilled product can lead to oxygen depletion in water and may adversely affect microorganisms and other aquatic life.
Waste Treatment Methods: Dispose of contents and containers in accordance with local, regional, national, and international regulations.
Contaminated Packaging: Empty containers should be triple rinsed prior to disposal or recycling.
Environmental Precautions for Disposal: Never pour into drains, watercourses, or soil. Use licensed chemical disposal contractors.
Disposal of Surplus Product: Treat as hazardous chemical waste; incineration under controlled conditions or specialized chemical landfill strongly recommended.
UN Number: Not classified as a dangerous good by transport regulations for typical solution strengths
Transport Hazard Class: Not regulated for ground, air, or sea at standard concentrations; bulk loads may vary—verify with transport authority
Packing Group: Not assigned
Special Precautions During Transport: Use sealed, well-marked containers. Secure load to prevent leakage and comply with local, state and international transport regulations.
Bulk Transport: Check regulations for specific guidance on transporting large quantities.
Occupational Exposure Standards: No specific OELs published, but observe good industrial hygiene practices.
Chemical Inventory Listings: Registered under US TSCA, EU REACH, China IECSC, Japan ENCS, Korea ECL, and other national lists.
Safety, Health, and Environmental Regulations: Subject to workplace hazardous chemicals regulations. Hazard Communication and proper labeling required on site.
Restrictions: Environmental release is restricted; follow rules for aquatic toxicity.
Labeling Requirements: Comply with GHS/CLP for hazard statements, pictograms, signal words, and precautionary measures.
Other Regulatory Status: Not subject to strict transport restrictions but regulated for workplace health and waste disposal.
